Dynamic Prediction of Cellular Responding Ion Radiation based on a modeling of P53 Stress Response Networks

P53 acts a vital role in controlling the cell cycle arrest and cell apoptosis by regulating the downstream genes and their signal pathways. To investigate the complicated responses of P53 under the continuous ion radiation (IR) in the cellular level, a dynamic model for the P53 stress response networks is proposed. The model can be used to simulate the dynamic processes of generating the double-strand breaks (DSBs) and their repairing, and ataxia telangiectasia mutated (ATM) activation, as well as the oscillations occurring in the P53-MDM2 feedback loop. Meanwhile, the plausible outcomes of cellular response are analyzed by comparing the predictive kinetics of P53 stress response networks under different IR dose domains and radiation time.