Neuromedicator - a disposable drug delivery system with silicon microprobes for neural research

Author

Spieth, S. ; Schumacher, A. ; Kallenbach, C. ; Messner, S. ; Zengerle, R.

Author_Institution

Inst. fur Mikro- und Informationstechnik, Hahn-Schickard-Gesellschaft e.V. (HSG-IMIT), Villingen-Schwenningen, Germany

fYear

2010

fDate

24-28 Jan. 2010

Firstpage

983

Lastpage

986

Abstract

We report on a novel disposable drug delivery system for neural research which allows to infuse 16 discrete liquid portions of 0.25 Â¿L directly into neural cell tissue. The system comprises an 11 Ã— 14.5 Ã— 3 mm³ fluidic chip with a pluggable electrical micro connector and two 8-mm-long micromachined silicon fluidic microprobes with a cross-sectional area of 250 Ã— 250 Â¿m². A pearl chain-like fluidic structure with spherical segments was developed which stores and predefines the required drug liquid portions for the whole time of operation. The micropump principle for liquid delivery is based on the local, irreversible thermal expansion of microspheres embedded into polydimethylsiloxane (PDMS).

Keywords

bioMEMS; biological tissues; cellular biophysics; drug delivery systems; electric connectors; microfluidics; micropumps; neurophysiology; polymers; printed circuits; silicon; thermal expansion; discrete liquid portions; disposable drug delivery system; embedded system; fluidic chip; irreversible thermal expansion; micromachined silicon fluidic microprobes; micropump principle; microstructured PCB; neural cell tissue; neural research; neuromedicator; pearl chain-like fluidic structure; pluggable electrical microconnector; polydimethylsiloxane; silicon microprobes; size 8 mm; spherical segments; Connectors; Drug delivery; Electrodes; Fabrication; Fluidic microsystems; Microfluidics; Pharmaceutical technology; Probes; Silicon; Thermal expansion;

fLanguage

English

Publisher

ieee

Conference_Titel

Micro Electro Mechanical Systems (MEMS), 2010 IEEE 23rd International Conference on

Conference_Location

Wanchai, Hong Kong

ISSN

1084-6999

Print_ISBN

978-1-4244-5761-8

Electronic_ISBN

1084-6999

Type

conf

DOI

10.1109/MEMSYS.2010.5442373

Filename

5442373