Title :
From the Pharmacokinetics to the Intracellular Dynamic Phase - Direct Introduction of Nanoparticles into Cytoplasm of Living Cells
Author_Institution :
Kobe Gakuin University
Abstract :
We developed a technology to directly introduce nanoparticles into the cytoplasm of living cells at one time without using a micromanipulator. Moreover, we confirmed that antisense oligonucleotides as a model drug can be released slowly in cytoplasm from these particles.
Keywords :
Biomembranes; Cells (biology); Drugs; Fluid flow measurement; Fluorescence; Micromanipulators; Microscopy; Nanoparticles; Pharmaceutical technology; Sugar;
Conference_Titel :
MEMS, NANO and Smart Systems, 2004. ICMENS 2004. Proceedings. 2004 International Conference on
Conference_Location :
Banff, AB, Canada
Print_ISBN :
0-7695-2189-4
DOI :
10.1109/ICMENS.2004.1509023
