Title :
In vivo molecular imaging in cells using time-resolved microspectrofluorimetry
Author_Institution :
Dept. of Biomedical Eng. & Appl. Phys. Program, Michigan Univ., Ann Arbor, MI, USA
Abstract :
Time-resolved laser spectroscopy and microscopy can be employed to sense endogenous and exogenous molecular compounds in living cells. We describe how the method is applied to detect in vivo molecular interactions with nanometer scale sensitivity.
Keywords :
biomedical optical imaging; cellular biophysics; fluorescence; molecular biophysics; optical microscopy; time resolved spectroscopy; endogenous molecular compounds; exogenous molecular compounds; in vivo molecular imaging; laser spectroscopy; living cells; time-resolved microspectrofluorimetry; Fluorescence; In vivo; Laser modes; Microscopy; Molecular imaging; Nanobioscience; Optical pulses; Pump lasers; Space vector pulse width modulation; Spectroscopy;
Conference_Titel :
Lasers and Electro-Optics Society, 2004. LEOS 2004. The 17th Annual Meeting of the IEEE
Print_ISBN :
0-7803-8557-8
DOI :
10.1109/LEOS.2004.1363568
