Modeling and simulation of a NEUOROBIOFET for application in neurology

Author

Deka, Rashmi ; Dutta, Jiten Ch

Author_Institution

Dept. of Electron. & Commun. Eng., Tezpur Univ., Tezpur, India

fYear

2015

fDate

29-30 Jan. 2015

Firstpage

100

Lastpage

104

Abstract

Acetylcholine sensitive field effect transistor (AchFET) has been modeled and simulated to use as circuit element in a neuron circuit. AchFET has been modeled using enzyme kinetics and site binding theory. Based on the simulated characteristics, it is used as an analog of variable conductance in the Hodgkin-Huxley electrical model of neuron that was used to study the resistance and capacitance properties of a patch of squid axon membrane. PSPICE simulation of the circuit using AchFET gives satisfactory reproduction of sodium and potassium currents and simulated electronic action potential is very similar to the experimentally recorded one. Due to the simplicity of this circuit, it may be used as an ideal unit in neurology to study the receptor function and electrical activity of neuron.

Keywords

SPICE; bioelectric potentials; biomedical electronics; biomedical equipment; biomembrane transport; capacitance; electrical conductivity; electrical resistivity; enzymes; ion sensitive field effect transistors; molecular biophysics; neurophysiology; semiconductor device models; NEUROBIOFET; PSPICE simulation; acetylcholine sensitive field effect transistor; capacitance properties; circuit element; enzyme kinetics; neurology; neuron Hodgkin-Huxley electrical model; neuron circuit; neuron electrical activity; potassium current; receptor function; resistance properties; site binding theory; sodium current; squid axon membrane; Biomembranes; Capacitance; Electric potential; Integrated circuit modeling; Nerve fibers; SPICE; AchFET; Axon; Hodgkin-Huxley model; Neuron; Receptor;

fLanguage

English

Publisher

ieee

Conference_Titel

Electronic Design, Computer Networks & Automated Verification (EDCAV), 2015 International Conference on

Conference_Location

Shillong

Print_ISBN

978-1-4799-6207-5

Type

conf

DOI

10.1109/EDCAV.2015.7060547

Filename

7060547