Title :
Injection Guidance System for Cellular Microinjections
Author :
Kallio, Pasi ; Ritala, Tuukka ; Lukkari, Mikko ; Kuikka, Seppo
Author_Institution :
Dept. of Autom. & Control, Tampere Univ. of Technol.
Abstract :
This paper will present a novel injection guidance system which assists an operator in the microinjection of living adherent cells. The system includes a micromanipulator, an injection system, an impedance measurement device and control software. The impedance measurement system detects changes in the impedance of an injection capillary during cell injections. From the measurement signal, the software determines parameters which can be used for detecting several injection events such as cell-capillary contact, capillary breakage and capillary clogging, which are all unavailable in the current microinjection systems
Keywords :
cellular biophysics; electric impedance measurement; medical robotics; micromanipulators; adherent cell; biomicromanipulator; capillary breakage; capillary clogging; cell-capillary contact; cellular microinjection; control software; impedance measurement device; injection capillary; injection guidance system; real-time software; Automatic control; Automation; Cells (biology); Control systems; Current measurement; Detection algorithms; Impedance measurement; Microinjection; Micromanipulators; Software measurement;
Conference_Titel :
Biomedical Robotics and Biomechatronics, 2006. BioRob 2006. The First IEEE/RAS-EMBS International Conference on
Conference_Location :
Pisa
Print_ISBN :
1-4244-0040-6
DOI :
10.1109/BIOROB.2006.1639171
