Injection Guidance System for Cellular Microinjections

Author

Kallio, Pasi ; Ritala, Tuukka ; Lukkari, Mikko ; Kuikka, Seppo

Author_Institution

Dept. of Autom. & Control, Tampere Univ. of Technol.

fYear

2006

fDate

20-22 Feb. 2006

Firstpage

696

Lastpage

701

Abstract

This paper will present a novel injection guidance system which assists an operator in the microinjection of living adherent cells. The system includes a micromanipulator, an injection system, an impedance measurement device and control software. The impedance measurement system detects changes in the impedance of an injection capillary during cell injections. From the measurement signal, the software determines parameters which can be used for detecting several injection events such as cell-capillary contact, capillary breakage and capillary clogging, which are all unavailable in the current microinjection systems

Keywords

cellular biophysics; electric impedance measurement; medical robotics; micromanipulators; adherent cell; biomicromanipulator; capillary breakage; capillary clogging; cell-capillary contact; cellular microinjection; control software; impedance measurement device; injection capillary; injection guidance system; real-time software; Automatic control; Automation; Cells (biology); Control systems; Current measurement; Detection algorithms; Impedance measurement; Microinjection; Micromanipulators; Software measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Robotics and Biomechatronics, 2006. BioRob 2006. The First IEEE/RAS-EMBS International Conference on

Conference_Location

Pisa

Print_ISBN

1-4244-0040-6

Type

conf

DOI

10.1109/BIOROB.2006.1639171

Filename

1639171