Simulation of effects of ischemia in 3D human ventricle

In this paper, we present an integrated model of 3D human ventricle to simulate the effects of ischemia on wave propagation. To deal with the no-flux boundary conditions, a phase-field method is employed. The major advantage of the method is that it can automatically handle the boundary conditions. Through the increasing of concentration of extracellular K⁺ and ischemic size, the propagation of spiral wave under different ischemia symptoms is simulated. The experimental results show that with the increasing of ischemia severity and ischemic size, spiral waves are more and more instable, but when the tip of spiral wave stays inside the ischemic region, the spiral wave maintains stabilization.