Positive correlation between heart rate variability and stochastic nervous modulation - a computer simulation study

Cardiac rhythm is irregular with heart rate varies from time to time. Heart rate variation (HRV) is clinically relevant and indicative of a pathological condition. However, the mechanisms underlying the HRV are still controversial and stochastic nervous modulation may be a major responsible factor. In this study, we implemented a computer simulation study to investigate a causative link between stochastic autonomic nervous modulation and the HRV. It was shown that stochastic activity of parasympathetic nerve system (i.e., by application of acetylcholine) produces varying rate of cardiac pacemaker potentials that presents "chaotic" characteristics although the underlying process is stochastic. A positive correlation between the measured time series of CL and ACh has also been revealed. This study provides a solid evidence to support the hypothesis that stochastic nervous modulation is associated with the HRV, which may be produced by a deterministic system driven by a stochastic process, even though it can show ¿chaotic¿ characteristics.