Title :
Detection of short exons in DNA sequences using complex wavelet transform of structural features
Author :
Provaznik, Ivo ; Kubicova, V. ; Skutkova, H. ; Nedved, J. ; Tkacz, E. ; Babula, P. ; Kizek, R.
Author_Institution :
Dept. of Biomed. Eng., Brno Univ. of Technol., Brno, Czech Republic
Abstract :
The paper presents a spectral method used for detection of short coding regions in genes. The complex representation of four nucleotides involving three basic chemical and structural properties is used for conversion of a symbolic sequence into a genomic signal. Another genomic signal is generated from dinucleotide propeller twist. Filtered complex combination of both signals is transformed by a complex continuous wavelet transform. Its results were analysed both in amplitude and phase parts. Experimental results obtained by this method are shown to be comparable or better than recently published methods based on the selected set of genes.
Keywords :
DNA; biochemistry; bioinformatics; genetics; genomics; molecular biophysics; molecular configurations; spectral analysis; wavelet transforms; DNA sequences; amplitude parts; chemical property; complex continuous wavelet transform; complex representation; dinucleotide propeller twist; filtered complex combination; genes; genomic signal; nucleotides; phase parts; short coding region detection; short exon detection; spectral method; structural features; structural property; symbolic sequence conversion; DNA sequence analysis; DNA structure; Exon detection; wavelet analysis;
Conference_Titel :
Genomic Signal Processing and Statistics, (GENSIPS), 2012 IEEE International Workshop on
Conference_Location :
Washington, DC
Print_ISBN :
978-1-4673-5234-5
DOI :
10.1109/GENSIPS.2012.6507740
