Biosensor Arrays based on Surface Plasmon Resonance Phase Imaging

In this paper we present a biosensor design based on phase imaging of surface plasmon resonance (SPR). The system is adapted from our previously reported differential phase measurement scheme. We first conducted experiments on measuring the concentration of salt concentration in water in order to demonstrate the operation of this system. Biosensing experiments were performed to monitor the H3 influenza antigen-antibody binding interaction. In recent years, the needs for high-throughput biosensors in life sciences and biomedical areas have been increasing rapidly. Our phase-imaging SPR sensor is a non-labeling, real-time quantitative sensing approach compatible with the micro-array chip platform. It should therefore have a promising potential for various bio-related detection applications, such as clinical diagnostics.