DocumentCode :
2052768
Title :
Comparison of imaging characteristics of Xe-133 and Xe-127 for use in dynamic brain SPECT: a Monte Carlo investigation
Author :
Pretorius, P. Hendrik ; Glick, Stephen J. ; De Vries, Daniel J. ; Licho, Robert ; King, Michael A.
Author_Institution :
Massachusetts Univ. Med. Center, Worcester, MA, USA
Volume :
2
fYear :
1999
fDate :
1999
Firstpage :
1005
Abstract :
The aim of the study was to determine the degree of improvement obtained by using Xe-127 as the imaging agent compared to Xe-133 for rCBF SPECT. The SIMIND Monte Carlo code was used to simulate projections of gray and white matter at a ratio of 4:1 using a realistic voxelized anthropomorphic brain phantom. Xe-133 and Xe-127 were simulated using high-sensitivity and medium-energy collimators respectively. Data were acquired into 64 projections of 128×128 matrix size. A Tc-99m HMPAO study was simulated as reference. Contrast calculations yielded values of 2.1:1, 1.8:1, and 1.3:1 between gray and white matter for Tc-99m, Xe-127, and Xe-133 respectively. A normalized profile through a transverse mid-brain slice demonstrates the improvement in resolution with Xe-127 compared to Xe-133. The difference in resolution between Tc-99m and Xe-127 are less pronounced. Further investigation is needed to study the noise characteristics of both Xenon isotopes for clinical rCBF studies. With Xe-127 and an optimized medium-energy high-resolution fan-beam collimator, it is likely that a notable increase in quantitative accuracy of rCBF estimation can be realized
Keywords :
Monte Carlo methods; brain; image resolution; medical image processing; single photon emission computed tomography; 127Xe SPECT; 133Xe SPECT; SIMIND Monte Carlo code; cerebral blood flow; contrast calculations; dynamic brain SPECT; gray matter; high-resolution fan-beam collimator; imaging characteristics; improved resolution; transverse mid-brain slice; voxelized anthropomorphic brain phantom; white matter; Biomedical imaging; Brain modeling; Collimators; Electromagnetic scattering; Isotopes; Monte Carlo methods; Particle scattering; Positron emission tomography; Single photon emission computed tomography; Xenon;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Nuclear Science Symposium, 1999. Conference Record. 1999 IEEE
Conference_Location :
Seattle, WA
ISSN :
1082-3654
Print_ISBN :
0-7803-5696-9
Type :
conf
DOI :
10.1109/NSSMIC.1999.845831
Filename :
845831
Link To Document :
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