A Novel Minimally Invasive Method to Detect Glucose Concentration without Blood Extraction

A novel minimally invasive way to measure the diabetic´s real-time blood glucose concentration in vitro is proposed by combining interstitial fluid transdermal extraction ultrasonically and surface plasma resonance detecting. Low-frequency ultrasound is employed to enhance the skin permeability to interstitial fluid by disrupting the stratum corneum lipid bilayers and then interstitial fluid is extracted out of skin successfully by vacuum. The glucose concentration in the interstitial fluid is measured by refractive index analyzing using microsystem technology basing surface plasma resonance sensor with microfluidic platform. The whole method and experimental system above is set up in the article and the feasibility of this new way for blood glucose detecting is primarily validated for clinical application with the requirements of bloodless, painless, continuous glucose monitoring. The detection resolution of glucose concentration in our current system is approximately 8 mg/dl. Additional a prototype of miniature diabetes monitoring device is also being developed