Title :
Infrared spectroscopic determination of drugs in saliva
Author :
Hans, Kerstin M -C ; Müller, Susanne ; Sigrist, Markus W.
Author_Institution :
Laser Spectrosc. & Sensing Lab., ETH Zurich, Zurich, Switzerland
Abstract :
We present a new approach based on attenuated total reflection spectroscopy in the infrared using a very simple one-step extraction method. The method also enables the design of a microfluidic device that could perform the extraction by itself. First measurements were done with a Fourier-Transform-Infrared spectrometer. Saliva samples were taken from human test persons and then spiked with caffeine, COC and metabolites. Afterwards the drugs were extracted with an organic solvent immiscible with water. After the phase separation the drugs were measured in the organic solvent.
Keywords :
Fourier transform spectroscopy; attenuated total reflection; biomedical measurement; drugs; infrared spectroscopy; microfluidics; organic compounds; spectrochemical analysis; Fourier-transform-infrared spectrometry; attenuated total reflection spectroscopy; drugs; infrared spectroscopic determination; microfluidic device; one-step extraction method; organic solvent; phase separation; saliva; Absorption; Driver circuits; Drugs; Performance evaluation; Quantum cascade lasers; Solvents; Spectroscopy;
Conference_Titel :
Lasers and Electro-Optics Europe (CLEO EUROPE/EQEC), 2011 Conference on and 12th European Quantum Electronics Conference
Conference_Location :
Munich
Print_ISBN :
978-1-4577-0533-5
Electronic_ISBN :
Pending
DOI :
10.1109/CLEOE.2011.5943085
