A Rapid and Cost Effective Method for Measurement of Cyclosporine

Author

Mirmohseni, Abdolreza ; Shojaei, Maryam ; Hosseini, Javad

Author_Institution

Dept. of Appl. Chem., Univ. of Tabriz, Tabriz, Iran

Volume

13

Issue

11

fYear

2013

fDate

Nov. 2013

Firstpage

4542

Lastpage

4545

Abstract

Cyclosporine, a powerful immunosuppressive agent, is used to prevent allograft rejection. This paper describes a simple, rapid, and cost effective method based on a quartz crystal nanobalance for the detection of cyclosporine. Measurement is based on the frequency shifts of a methyl phenyl silicon, 75% phenyl (OV25)-coated quartz crystal because of the adsorption of analytes. The frequency shift of sensor is linear related to the concentration of cyclosporine in solution. Linear calibration curve is obtained in the range of 2-8 mg L^-1. The correlation coefficient and the lower limit detection are 0.993 and 0.94 ppm, respectively.

Keywords

adsorption; biochemistry; calibration; correlation methods; drugs; organic compounds; quartz crystal microbalances; allograft rejection prevention; analytes adsorption; correlation coefficient; cyclosporine measurement; frequency shift; immunosuppressive agent; linear calibration curve; methyl phenyl silicon; quartz crystal nanobalance; Cyclosporine; quartz crystal nanobalance; sensor; silicon-OV25;

fLanguage

English

Journal_Title

Sensors Journal, IEEE

Publisher

ieee

ISSN

1530-437X

Type

jour

DOI

10.1109/JSEN.2013.2269533

Filename

6542728