A Rapid and Cost Effective Method for Measurement of Cyclosporine

Cyclosporine, a powerful immunosuppressive agent, is used to prevent allograft rejection. This paper describes a simple, rapid, and cost effective method based on a quartz crystal nanobalance for the detection of cyclosporine. Measurement is based on the frequency shifts of a methyl phenyl silicon, 75% phenyl (OV25)-coated quartz crystal because of the adsorption of analytes. The frequency shift of sensor is linear related to the concentration of cyclosporine in solution. Linear calibration curve is obtained in the range of 2-8 mg L^-1. The correlation coefficient and the lower limit detection are 0.993 and 0.94 ppm, respectively.