Title :
Frequency-domain analysis for intron prediction
Author :
Papaspiridis, Alexandros A.
Author_Institution :
Dept. of Electr. & Electron. Eng., Imperial Coll. London, London, UK
Abstract :
It has been shown that gene-coding regions exhibit a strong 3 base-pair (bp) periodicity. As a result of this property, the gene-coding regions within a DNA sequence may be predicted by performing a frequency-domain analysis of the sequence. Developing on this concept, a second periodicity known to be present in DNA sequences is on average equal to 10.4hp, and this corresponds to the helical periodicity or the number of bases in a complete turn of the double helix. The frequency-domain analysis was expanded to examine for the helical periodicity in order to predict regions that are not responsible for gene-coding.
Keywords :
DNA; bioinformatics; frequency-domain analysis; molecular biophysics; molecular configurations; DNA sequence; base-pair periodicity; double helix; frequency-domain analysis; gene-coding regions; helical periodicity; intron prediction; Bioinformatics; DNA; Educational institutions; Genomics; Biomolecular sequences; exon prediction; frequency-domain analysis; gene prediction; intron prediction; short-time Fourier Transform;
Conference_Titel :
Information Technology and Applications in Biomedicine (ITAB), 2010 10th IEEE International Conference on
Conference_Location :
Corfu
Print_ISBN :
978-1-4244-6559-0
DOI :
10.1109/ITAB.2010.5687682
