Title :
Dual energy pulses for Electrical Impedance Spectroscopy with the stochastic Gabor function
Author :
Bonmassar, Giorgio ; Iacono, Maria I. ; Lev, M.H.
Author_Institution :
Med. Sch., A.A. Martinos Center, Harvard Univ., Charlestown, MA, USA
fDate :
Aug. 28 2012-Sept. 1 2012
Abstract :
This paper introduces the stochastic Gabor function (SGF), an excitation waveform that can be used to design optimal excitation pulses for Electrical Impedance Spectroscopy (EIS) of the brain. The SGF is a Gaussian function modulated by uniformly distributed noise; it has wide frequency spectrum representation regardless of the stimuli pulse length. The SGF was studied in the time-frequency domain. As shown by frequency concentration measurements, the SGF is least compact in the sample frequency phase plane. Numerical results obtained by using a realistic human head model indicate that the SGF may allow for both shallow and deeper tissue penetration than is currently obtainable with conventional stimulus paradigms, potentially facilitating tissue subtraction assessment of parenchymal dielectric changes in frequency. This could be of value in advancing EIS of stroke and hemorrhage.
Keywords :
Gaussian distribution; bioelectric phenomena; biological tissues; biomedical measurement; brain; electric impedance measurement; noise; time-frequency analysis; EIS; Gaussian function; SGF; brain; dual energy pulses; electrical impedance spectroscopy; excitation waveform; frequency concentration measurements; frequency spectrum representation; hemorrhage; optimal excitation pulses; parenchymal dielectric changes; realistic human head model; sample frequency phase plane; stimuli pulse length; stochastic Gabor function; stroke; time-frequency domain; tissue penetration; tissue subtraction assessment; uniformly distributed noise; Head; Impedance; Shape; Spectroscopy; Stochastic processes; Time domain analysis; Time frequency analysis; Dielectric Spectroscopy; Head; Humans; Intracranial Hemorrhages; Stochastic Processes; Stroke;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE
Conference_Location :
San Diego, CA
Print_ISBN :
978-1-4244-4119-8
Electronic_ISBN :
1557-170X
DOI :
10.1109/EMBC.2012.6345890