Title :
Concept of Associated Photodynamic Therapy with Porphyrin – Cis-Platin Drug System and Applications on HeLa Cells
Author :
Ion, Rodica Mariana ; Maresca, Luciana ; Migoni, Danilo ; Fanizzi, Francesco P.
Author_Institution :
Anal. Dept., ICECHIM, Bucharest
fDate :
June 29 2008-July 5 2008
Abstract :
Photodynamic therapy (PDT) is a clinical approach that uses light-activated drugs for the treatment of different kind of tumor tissues. HeLa tumor cells, as an experimental model for studying the new biomedical concept of associated PDT with 5, 10, 15, 20 -sulphonato-phenyl-porphyrin (TSPP) and an antitumor agent - cisplatin (CisPt), yielded to an enhanced effect on the suppression of tumor cells in vitro. The ultra structure changes of cells caused by the action of the new concept and laser irradiation were analyzed, putting into evidence linear survival curves, by the linear quadratic model.
Keywords :
cancer; cellular biophysics; drugs; laser applications in medicine; photodynamic therapy; tumours; HeLa tumor cells; antitumor agent; cis-platin drug system; laser irradiation; light-activated drugs; linear quadratic model; linear survival curves; photodynamic therapy; porphyrin; tumor tissues; Bioinformatics; Biomembranes; Chemicals; Drugs; In vitro; Laser modes; Laser transitions; Medical treatment; Neoplasms; Tumors; CisPt; HeLa; photodynamic therapy; porphyrin;
Conference_Titel :
Biocomputation, Bioinformatics, and Biomedical Technologies, 2008. BIOTECHNO '08. International Conference on
Conference_Location :
Bucharest
Print_ISBN :
978-0-7695-3191-5
Electronic_ISBN :
978-0-7695-3191-5
DOI :
10.1109/BIOTECHNO.2008.35
