Luminescence diffuse optical tomography on a reflectance imaging set-up

Luminescence diffuse optical tomography has become a valuable tool in optical molecular imaging. As an actor of this recent field, the French company Quidd has developed a luminescence reflectance imaging system for small animal in vivo imaging. In previous studies, the authors have determined the potential and the limits of such approaches for the determination of the depth of fluorophores/bioluminescent substrates in tissues. In the present work, the authors have demonstrated the first reconstructions on test samples. For this study, the authors used a prototype of the Quidd optical system (QOS) as well as calibrated phantom and source.