Title :
An Epidemiological population study reveals a sex-related differential effect of PAH exposure and gene polymorphisms on bulky DNA adducts formation
Author :
Ladoukakis, Efthymios ; Georgiadis, Panagiotis ; Chatziioannou, Aristotelis
Author_Institution :
Nat. Tech. Univ. of Athens, Athens, Greece
Abstract :
DNA adducts have been recognized by many studies as biologically effective dose markers of exposure to carcinogen substances. In this epidemiological study, 194 inhabitants of two Greek cities, Athens and Halkida, are examined in order to investigate the quantitative relationships between exposure of the general population to urban air pollutants such as PAHs and various biomarkers of exposure, susceptibility and early biological effects. This study supports a sex-related differential effect of PAH exposure with respect to the implication of given cytochrome P450 enzyme family gene polymorphisms on bulky DNA adducts formation.
Keywords :
air pollution; diseases; genetics; molecular biophysics; molecular configurations; polymorphism; Athens; Greece; Halkida; P450 enzyme family gene polymorphisms; PAH exposure sex-related differential effect; biological effects; biomarkers; bulky DNA adduct formation; epidemiological population; gene polymorphisms; polycyclic aromatic hydrocarbons; urban air pollutants; Analysis of variance; Analytical models; Biological system modeling; Cities and towns; Computational modeling; DNA; Facsimile;
Conference_Titel :
Information Technology and Applications in Biomedicine (ITAB), 2010 10th IEEE International Conference on
Conference_Location :
Corfu
Print_ISBN :
978-1-4244-6559-0
DOI :
10.1109/ITAB.2010.5687782
