Title :
Low-cost, flexible polymer arrays for long-term neuronal culture
Author :
Hogan, N.C. ; Talei-Franzesi, G. ; Abudayyeh, O. ; Taberner, A. ; Hunter, I.
Author_Institution :
Mech. Eng. Dept., Massachusetts Inst. of Technol., Cambridge, MA, USA
fDate :
Aug. 28 2012-Sept. 1 2012
Abstract :
Conducting polymers are promising materials for fabrication of microelectrode arrays for both neural stimulation and recording. Our ability to engineer the morphology and composition of polypyrrole together with its suitability as an electrically addressable tissue/cell substrate have been used to develop an inexpensive, disposable three-dimensional polymeric array for use in neuronal culture and drug discovery. These arrays could be interfaced with a fixed, parallel stimulation and optical imaging system, amenable to automated handling and data analysis.
Keywords :
biological tissues; biomedical electrodes; biomedical materials; cellular biophysics; conducting polymers; microelectrodes; neurophysiology; automated handling; conducting polymers; data analysis; disposable three-dimensional polymeric array; drug discovery; electrically addressable tissue-cell substrate; flexible polymer arrays; inexpensive three-dimensional polymeric array; long-term neuronal culture; low-cost polymer arrays; microelectrode array fabrication; neural recording; neural stimulation; optical imaging system; parallel stimulation; polypyrrole; Conductivity; Fabrication; Microelectrodes; Neurons; Polymers; Surface treatment; Animals; Biocompatible Materials; Cell Culture Techniques; Computer-Aided Design; Electric Conductivity; High-Throughput Screening Assays; Hippocampus; Materials Testing; Mice; Microelectrodes; Microscopy, Electron, Scanning; Neuronal Plasticity; Neurons; Polymers; Pyrroles;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE
Conference_Location :
San Diego, CA
Print_ISBN :
978-1-4244-4119-8
Electronic_ISBN :
1557-170X
DOI :
10.1109/EMBC.2012.6346053
