Title :
A general model to analyze DNA methylation effect on transcription factors binding ability
Author :
Feng, Weixing ; Wang, Kejun ; He, Bo
Author_Institution :
Autom. Coll., Harbin Eng. Univ., Harbin, China
Abstract :
DNA methylation is identified as an elaborate epigenetic element to regulate binding of transcription factor to gene promoter region. With latest highthroughput technology, it is convenient to accurately test methylation level in experiment, which opens a door to investigate how methylation affects transcription factor. In this study, a general model is presented to depict methylation function, where parameters of model are fixed by analysis of relativity between transcription factor binding scores in promoter regions and gene expression levels. In neuroblastoma cell, with the deduced model, 10 transcriptional factors were found to be apparently affected by methylation of promoter regions.
Keywords :
DNA; association; cellular biophysics; molecular biophysics; DNA methylation effect; gene expression levels; gene promoter region; high throughput technology; methylation function; methylation level testing; neuroblastoma cell; transcription factor binding ability; transcription factor binding regulation; transcription factor binding scores; Variable speed drives; Analysis; Binding ability; DNA Methylation; Transcription factor;
Conference_Titel :
Progress in Informatics and Computing (PIC), 2010 IEEE International Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-6788-4
DOI :
10.1109/PIC.2010.5687975
