Simulation of digoxin single molecule detection through resonant frequency shift of a CNT

Author

Abbasi, Ali ; Nikfarjam, A. ; Mohammadnejad, J.

Author_Institution

Fac. of New Sci. & Technol., Univ. of Tehran, Tehran, Iran

fYear

2013

fDate

13-15 Feb. 2013

Firstpage

352

Lastpage

355

Abstract

In this paper, the possibility of using natural resonant frequency shift of a Carbon Nanotube (CNT) as a bio sensor has been studied. The frequency shift of a CNT cantilever beam oscillator due to the placement of a single Digoxin bio molecule has been studied. Digoxin is widely used as a cardiac glycoside drug in the treatment of various heart conditions. Since, it is a toxic drug, it should be regularly monitored in the serum of patients under treatment. In this study the effect of changing diameter and length of the CNT cantilever beam has been analyzed. Frequency shifts has been analyzed by continuum mechanics and CNT has been equalized by a shell. Required processes have been done using Finite Element Method (FEM). Simulation shows that decreasing the length and radius of the CNT caused the sensitivity to increase.

Keywords

biosensors; carbon nanotubes; finite element analysis; CNT; FEM; biosensor; cantilever beam oscillator; carbon nanotube; cardiac glycoside drug; digoxin biomolecule; digoxin single molecule detection; finite element method; natural resonant frequency shift; Electrostatics; Irrigation; Bio sensor; Carbon Nano Tube (CNT); Continuum Mechanics; Digoxin; Frequency Shift;

fLanguage

English

Publisher

ieee

Conference_Titel

Robotics and Mechatronics (ICRoM), 2013 First RSI/ISM International Conference on

Conference_Location

Tehran

Print_ISBN

978-1-4673-5809-5

Type

conf

DOI

10.1109/ICRoM.2013.6510132

Filename

6510132