DocumentCode :
2083109
Title :
Electrode robustness in artificial cerebrospinal fluid for dielectrophoresis-based LoC
Author :
Miled, M.A. ; Sawan, Mohamad
Author_Institution :
Electr. Eng. Dept., Ecole Polytech. de Montreal, Montreal, QC, Canada
fYear :
2012
fDate :
Aug. 28 2012-Sept. 1 2012
Firstpage :
1390
Lastpage :
1393
Abstract :
In this paper, we present hybrid microelectronics / microfluidic Lab-on-Chip (LoC) platform intended for implantable medical microsystems for neurotransmitter detection. In vitro experiments were achieved using artificial cerebrospinal fluid (ACSF) from Tocris Bioscience where microspheres were immersed to test the behaviour of the designed LoC. One of main features of the proposed LoC platform is its thin thickness, including micro-channels and silicon CMOS chip. The latter is integrated into the glass top-layer of the LoC measuring 0.5 mm. The size of the device is 9 mm × 5 mm. the electrode architecture is composed of 8×2×2 L-shaped electrodes in a 650 μm channel width and 4 sites for interdigitited electrodes. 32 L-shaped electrodes were connected to a electronics circuit for cells manipulation using dielectrophoresis (DEP). The described LoC achieved an efficient separation within a concentration of 50 μl of a solution of microspheres, distilled water (DW) and 500 μl of ACSF. Beyond this concentration, electrode destruction was observed.
Keywords :
CMOS integrated circuits; bioMEMS; biological techniques; biomedical electrodes; brain; cellular biophysics; electrophoresis; elemental semiconductors; lab-on-a-chip; microfluidics; neurophysiology; prosthetics; silicon; L-shaped electrodes; Si; Tocris bioscience; artificial cerebrospinal fluid; cell manipulation; dielectrophoresis-based lab-on-a-chip; distilled water; electrode architecture; electrode destruction; electrode robustness; electronics circuit; glass top-layer; hybrid microelectronics-microfluidic lab-on-chip platform; implantable medical microsystems; in vitro experiments; interdigitited electrodes; microchannels; microsphere solution; neurotransmitter detection; silicon CMOS chip; size 650 mum; CMOS integrated circuits; Dielectrophoresis; Electrodes; Glass; Microelectronics; Polymers; Cerebrospinal Fluid; Electrodes, Implanted; Electrophoresis; Humans; Microelectrodes; Microfluidic Analytical Techniques; Models, Biological;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE
Conference_Location :
San Diego, CA
ISSN :
1557-170X
Print_ISBN :
978-1-4244-4119-8
Electronic_ISBN :
1557-170X
Type :
conf
DOI :
10.1109/EMBC.2012.6346198
Filename :
6346198
Link To Document :
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