Title :
Experimental glucose regulation with a High-Order Sliding-Mode Controller
Author :
Gallardo Hernandez, Ana ; Revilla Monsalve, Cristina ; Fridman, L. ; Leder, Ron ; Islas Andrade, Sergio ; Shtessel, Yuri
Author_Institution :
Unidad de Investig. en Enfermedades Metabolicas, Centro Medico Nac. Siglo XXI (IMSS), Mexico City, Mexico
fDate :
Aug. 28 2012-Sept. 1 2012
Abstract :
Theoretically High-Order Sliding-Mode Controllers are well suited to perform closed loop glucose regulation because they are insensitive to parameter uncertainties and robust to unknown dynamics that may perturb the system. The implementation of the controller based on the concept of practical relative degree is presented. The controller was tested in Sprague-Dawley rats with steptozotocin induced diabetes. The tests demonstrated high efficacy and robustness of the controller.
Keywords :
biochemistry; blood; closed loop systems; diseases; medical control systems; robust control; variable structure systems; Sprague-Dawley rats; closed loop glucose regulation; high-order sliding-mode controllers; practical relative degree; robustness; steptozotocin induced diabetes; Biological system modeling; Diabetes; Insulin; Mathematical model; Rats; Robustness; Sugar; Animals; Blood Glucose; Computer Simulation; Diabetes Mellitus, Experimental; Drug Therapy, Computer-Assisted; Feedback, Physiological; Female; Hypoglycemic Agents; Insulin; Models, Biological; Rats; Streptozocin; Treatment Outcome;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE
Conference_Location :
San Diego, CA
Print_ISBN :
978-1-4244-4119-8
Electronic_ISBN :
1557-170X
DOI :
10.1109/EMBC.2012.6346363
