Experimental glucose regulation with a High-Order Sliding-Mode Controller

Author

Gallardo Hernandez, Ana ; Revilla Monsalve, Cristina ; Fridman, L. ; Leder, Ron ; Islas Andrade, Sergio ; Shtessel, Yuri

Author_Institution

Unidad de Investig. en Enfermedades Metabolicas, Centro Medico Nac. Siglo XXI (IMSS), Mexico City, Mexico

fYear

2012

fDate

Aug. 28 2012-Sept. 1 2012

Firstpage

2056

Lastpage

2059

Abstract

Theoretically High-Order Sliding-Mode Controllers are well suited to perform closed loop glucose regulation because they are insensitive to parameter uncertainties and robust to unknown dynamics that may perturb the system. The implementation of the controller based on the concept of practical relative degree is presented. The controller was tested in Sprague-Dawley rats with steptozotocin induced diabetes. The tests demonstrated high efficacy and robustness of the controller.

Keywords

biochemistry; blood; closed loop systems; diseases; medical control systems; robust control; variable structure systems; Sprague-Dawley rats; closed loop glucose regulation; high-order sliding-mode controllers; practical relative degree; robustness; steptozotocin induced diabetes; Biological system modeling; Diabetes; Insulin; Mathematical model; Rats; Robustness; Sugar; Animals; Blood Glucose; Computer Simulation; Diabetes Mellitus, Experimental; Drug Therapy, Computer-Assisted; Feedback, Physiological; Female; Hypoglycemic Agents; Insulin; Models, Biological; Rats; Streptozocin; Treatment Outcome;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE

Conference_Location

San Diego, CA

ISSN

1557-170X

Print_ISBN

978-1-4244-4119-8

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/EMBC.2012.6346363

Filename

6346363