Injectable macroporous microparticles for soft tissue augmentation

Author

Corrin, A.A. ; Ngai, M. ; Walthers, C.M. ; Dunn, J.C.Y. ; Wu, B.M.

Author_Institution

Bioeng. Dept., Univ. of California Los Angeles, Los Angeles, CA, USA

fYear

2012

fDate

Aug. 28 2012-Sept. 1 2012

Firstpage

2428

Lastpage

2431

Abstract

Macroporous polymeric microparticles have been fabricated using a combination of particulate leaching and gas foaming techniques. Controlling the concentration of ammonium bicarbonate particles and the spin speed of the microemulsion in poly (ε-caprolactone) (PCL) yields a range of macroporous microparticles with interconnected pores (10-50μm) that may promote cell and tissue ingrowth in vivo when implanted subcutaneously. This fabrication technique introduces a novel template which can be modified to meet a diverse set of material and biological specifications.

Keywords

biomedical materials; cellular biophysics; leaching; microemulsions; polymer foams; porosity; porous materials; tissue engineering; ammonium bicarbonate particles; biological specifications; cell ingrowth; gas foaming; injectable macroporous microparticles; interconnected pores; macroporous polymeric microparticles; material specifications; microemulsion; particulate leaching; poly(ε-caprolactone); size 10 mum to 50 mum; soft tissue augmentation; spin speed; tissue ingrowth; Fabrication; Leaching; Plastics; Scanning electron microscopy; Surface morphology; Surface treatment; Biomimetic Materials; Cosmetics; Injections; Materials Testing; Microspheres; Polyesters; Porosity;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE

Conference_Location

San Diego, CA

ISSN

1557-170X

Print_ISBN

978-1-4244-4119-8

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/EMBC.2012.6346454

Filename

6346454