Title :
Effect of Inhibition of Water-Soluble Propolis Extracts (WSPE) on biomolecules Damage Induced by Peroxynitrte
Author :
Luo, Yunjing ; Liu, Liya ; Gong, Ping ; Zhong, Rugang
Author_Institution :
Beijing Univ. of Technol., Beijing
Abstract :
Peroxynitrite (ONOO-) is a cytotoxicant with strong oxidizing and nitrating properties toward various biomolecules, including amino acids, DNA, lipids and proteins, thus can cause cell death, carcinogenesis or aging. The aim of this study was to investigate whether water-soluble propolis extracts (WSPE) could scavenge peroxynitre and further inhibit peroxynitrite-mediated tyrosine nitration, DNA strand breaks and low density lipoprotein (LDL) oxidation. The results show that WSPE have a strong ability to scavenge ONOO-, and its inhibition on ONOO- exhibited a concentration-dependent manner. It is suggested that propolis extracts might be developed as an effective peroxynitrite inhibitor for the prevention of ONOO- involved diseases.
Keywords :
biochemistry; biohazards; cellular biophysics; diseases; molecular biophysics; oxidation; proteins; toxicology; DNA; DNA strand breakage; ONOO- involved diseases; WSPE scavenging activity; amino acids; biomolecules damage inhibitory effects; carcinogenesis; cell aging; cell death; cytotoxicant; disease prevention; lipids; low density lipoprotein oxidation; nitrating properties; oxidizing properties; peroxynitrite inhibitor; peroxynitrite-mediated tyrosine nitration; proteins; water-soluble propolis extracts; Alzheimer´s disease; Amino acids; Biochemistry; Chemicals; DNA; Inhibitors; Lipidomics; Molecular biophysics; Oxidation; Proteins;
Conference_Titel :
Complex Medical Engineering, 2007. CME 2007. IEEE/ICME International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-1077-4
Electronic_ISBN :
978-1-4244-1078-1
DOI :
10.1109/ICCME.2007.4382092
