2-D images for biopsy guidance and 3-D images for treatment planning and monitoring of prostate cancer based upon spectrum analysis and neural-network classification

Spectrum analysis of ultrasonic echo signals has been showing potential for distinguishing cancerous from non-cancerous prostate tissues. Recently, using neural networks to classify tissue from spectrum analysis results has provided a powerful basis for imaging, guiding biopsies, and planning, executing, and monitoring therapy. ROC curves derived from leave-one-out evaluations of neural-network classifier performance have an area of 0.87±0.04 compared to an area of 0.64±0.04 for B-mode methods, which implies significantly superior differentiation of cancerous from non-cancerous prostate tissue