Synthesis and Characterization of 5-(4-(3-Trimethoxysilyl)Propoxy)Phenyl)-1H-Tetrazole

N-heterocyclic molecules, bearing nitrogen atoms and conjugate ring and having protogenic proton conductivity, can be used as proton conducting functional group for proton exchange membrane (PEM). In this paper, 5-(4-hydroxyphenyl)-¹H-tetrazole (b) was synthesized using 4-cyanophenol (a) and sodium azide as main materials and water as solvent by click chemistry. The optimum reaction conditions were obtained by orthogonal test design and single factor experiments. The yield of (b) was 92.5% under n(4-cyanophenol): n(NaN₃)=1:l.4, reflux at 115°C for 24h, acidifying at 50°C for 1.5h. Then 5-(4-(3-trimethoxy-silyl)-propoxy)phenyl)-¹H-tetrazole(c) was formed by condensation using (3- chloropropyl) trimethoxysilane as precursor. The structures of (b) and proposed (c) were supported by FTIR, ¹HNMR and ¹³CNMR. The results showed that this synthetic process was environmental benign due to water solvent and little waste discharge.