Title :
Label-free, single molecule detection of cytokines using optical microcavities
Author :
Armani, Andrea M. ; Fraser, Scott E. ; Vahala, Kerry J.
Author_Institution :
California Inst. of Technol., Pasadena
Abstract :
Interleukin-2 (IL2) is a cytokine that regulates T-cell growth and is used in cancer therapies. By sensitizing a microcavity sensor surface with anti-IL2 and monitoring the resonant frequency, single molecules of IL2 can be detected.
Keywords :
biological techniques; cancer; cellular biophysics; microcavities; microsensors; molecular biophysics; optical sensors; proteins; T-cell growth; cancer therapies; cytokines; interleukin-2; microcavity sensor; optical microcavities; resonant frequency; single molecule detection; Biomedical optical imaging; Microcavities; Optical refraction; Optical resonators; Optical sensors; Optical surface waves; Optical variables control; Optical waveguides; Resonance; Sensor arrays;
Conference_Titel :
Lasers and Electro-Optics Society, 2007. LEOS 2007. The 20th Annual Meeting of the IEEE
Conference_Location :
Lake Buena Vista, FL
Print_ISBN :
978-1-4244-0925-9
Electronic_ISBN :
1092-8081
DOI :
10.1109/LEOS.2007.4382547
