DocumentCode :
2104143
Title :
Effect of hypothermia on the thalamocortical function in the rat model
Author :
Maybhate, Anil ; Cheng Chen ; Thakor, Nitish V. ; Xiaofeng Jia
Author_Institution :
Dept. of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA
fYear :
2012
fDate :
Aug. 28 2012-Sept. 1 2012
Firstpage :
4680
Lastpage :
4683
Abstract :
Neuroprotective effects of hypothermia are well documented in many injuries of the central nervous system in animal models as well as clinical studies. However, the underlying mechanisms are not fully understood. An important yet unexplored background issue is the effect of hypothermic cooling on the regional functionality of the healthy CNS. In a pilot study with the rat model, we seek to characterize the effect of moderate bodily cooling on the thalamo-cortical (T-C) function. Multiunit activity (MUA) and local field potentials (LFPs) were recorded from the thalamus (VPL nucleus) and the somatosensory cortex (S1) for normothermic, mild hypothermic and mild hyperthermic conditions in healthy rats and the thalamo-cortical dynamics was characterized with Granger Causal Interaction (GCI). The GCI indicated that the thalamic driving of the cortical activity significantly increases in strength with bodily cooling and weakens with mild heating. These results could have important implications towards understanding of hypothermia.
Keywords :
biomedical measurement; biothermics; brain; neurophysiology; CNS regional functionality; Granger causal interaction; LFP; MUA; VPL nucleus; animal models; central nervous system injuries; healthy CNS; hypothermia effects; hypothermia neuroprotective effects; hypothermic cooling; local field potentials; mild hyperthermic conditions; mild hypothermic conditions; moderate bodily cooling; multiunit activity; normothermic conditions; rat model; somatosensory cortex; thalamocortical function; thalamus; Band pass filters; Brain modeling; Cooling; Hyperthermia; Injuries; Rats; Spinal cord injury; Action Potentials; Animals; Hypothermia; Male; Neural Pathways; Rats; Rats, Wistar; Somatosensory Cortex; Thalamic Nuclei;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE
Conference_Location :
San Diego, CA
ISSN :
1557-170X
Print_ISBN :
978-1-4244-4119-8
Electronic_ISBN :
1557-170X
Type :
conf
DOI :
10.1109/EMBC.2012.6347011
Filename :
6347011
Link To Document :
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