Parameter estimation of the Huxley cross-bridge muscle model in humans

Author

Vardy, A.N. ; de Vlugt, E. ; van der Helm, Frans C. T.

Author_Institution

Dept. of Biomech. Eng., Delft Univ. of Technol., Delft, Netherlands

fYear

2012

fDate

Aug. 28 2012-Sept. 1 2012

Firstpage

4827

Lastpage

4830

Abstract

The Huxley model has the potential to provide more accurate muscle dynamics while affording a physiological interpretation at cross-bridge level. By perturbing the wrist at different velocities and initial force levels, reliable Huxley model parameters were estimated in humans in vivo using a Huxley muscle-tendon complex. We conclude that these estimates may be used to investigate and monitor changes in microscopic elements of muscle functioning from experiments at joint level.

Keywords

biomechanics; electromyography; parameter estimation; perturbation theory; Huxley cross-bridge muscle model; Huxley muscle-tendon complex; electromyograms; initial force levels; joint level; microscopic elements; muscle dynamics; muscle functioning; parameter estimation; perturbation; physiological interpretation; velocity; wrist; Biological system modeling; Biomechanics; In vivo; Joints; Muscles; Tendons; Wrist; Algorithms; Computer Simulation; Female; Humans; Male; Models, Biological; Muscle Contraction; Muscle, Skeletal; Range of Motion, Articular; Tendons; Wrist Joint;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE

Conference_Location

San Diego, CA

ISSN

1557-170X

Print_ISBN

978-1-4244-4119-8

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/EMBC.2012.6347074

Filename

6347074