A 128 /spl times/ 128 CMOS bio-sensor array for extracellular recording of neural activity

Author

Eversmann, B. ; Jenkner, M. ; Paulus, C. ; Hofmann, F. ; Brederlow, R. ; Holzapfl, B. ; Fromherz, P. ; Brenner, M. ; Schreiter, M. ; Gabl, R. ; Plehnert, K. ; Steinhauser, M. ; Eckstein, G. ; Schmitt-Landsiedel, D. ; Thewes, R.

Author_Institution

Corporate Res., Infineon Technol. AG, Munich, Germany

fYear

2003

fDate

13-13 Feb. 2003

Firstpage

222

Abstract

A CMOS sensor array for monitoring neural signals of living cells with 128 /spl times/ 128 pixels in a 1 mm/sup 2/ area is described. A standard 0.5 /spl mu/m, 5 V CMOS process extended by top electrodes covered by a relatively thin bio-compatible dielectric is used. Detection circuitry is based on a sensor-MOSFET mismatch-compensating current-mode technique.

Keywords

CMOS integrated circuits; array signal processing; bioelectric potentials; biological techniques; biomedical electronics; biomembrane transport; current-mode circuits; medical signal detection; mixed analogue-digital integrated circuits; neurophysiology; 0.5 micron; 128 pixel; 16384 pixel; 5 V; CMOS bio-sensor array; detection circuitry; extracellular recording; living cells; neural activity; neural signal monitoring; sensor-MOSFET mismatch-compensating current-mode technique; thin bio-compatible dielectric; top electrodes; Biomembranes; Biosensors; CMOS process; Cells (biology); Dielectrics; Electrodes; Extracellular; MOSFET circuits; Sensor arrays; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Circuits Conference, 2003. Digest of Technical Papers. ISSCC. 2003 IEEE International

Conference_Location

San Francisco, CA, USA

ISSN

0193-6530

Print_ISBN

0-7803-7707-9

Type

conf

DOI

10.1109/ISSCC.2003.1234276

Filename

1234276