Title :
Signal transduction on enzymes: the Effect of electromagnetic field stimuli on superoxide dismutase (SOD)
Author :
Marracino, P. ; Migliorati, M. ; Paffi, Alessandra ; Liberti, Micaela ; Denzi, Agnese ; d´Inzeo, G. ; Apollonio, Francesca
fDate :
Aug. 28 2012-Sept. 1 2012
Abstract :
Protein functions and characteristics can highly differ from physiological conditions in presence of chemical, mechanical or electromagnetic stimuli. In this work we provide a rigorous picture of electric field effects on proteins behavior investigating, at atomistic details, the possible ways in which an external signal can be transduced into biochemical effects. Results from molecular dynamics (MD) simulations of a single superoxidismutase (SOD) enzyme in presence of high exogenous alternate electric fields will be discussed.
Keywords :
biochemistry; bioelectric phenomena; electromagnetic fields; enzymes; molecular dynamics method; biochemical effects; chemical stimuli; electric field effects; electromagnetic field stimuli effect; enzymes; high exogenous alternate electric fields; mechanical stimuli; molecular dynamics simulations; physiological conditions; protein characteristics; protein functions; signal transduction; superoxide dismutase; Biological system modeling; Electric fields; Microwave oscillators; Physiology; Proteins; Spectrogram; Electromagnetic Fields; Models, Molecular; Molecular Dynamics Simulation; Signal Transduction; Superoxide Dismutase;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE
Conference_Location :
San Diego, CA
Print_ISBN :
978-1-4244-4119-8
Electronic_ISBN :
1557-170X
DOI :
10.1109/EMBC.2012.6347282
