Prediction of recombination rate in the human genome

Meiotic recombination does not occur randomly across the genome. Recombination depends on the primary sequence of genome and chromatin structure. In this study, the correlation of recombination rate with GC content and dinucleotide abundance is explored, and then 1-Megabase scale recombination rate is predicted by using the method of diversity measure combined with quadratic discriminant analysis based on the mononucleotide and dinucleotide occurrences. The result shows that the total prediction accuracies are about 70% for both the regions of high recombination rates and those of low recombination rates.