Title :
Photonic crystal biosensor with in-situ synthesized DNA probes for enhanced sensitivity
Author :
Hu, Song ; Zhao, Yiwen ; Retterer, S.T. ; Kravchenko, I.I. ; Weiss, S.M.
Author_Institution :
Dept. of Phys. & Astron., Vanderbilt Univ., Nashville, TN, USA
Abstract :
We report on a nearly 8-fold increase in multi-hole defect photonic crystal biosensor response by incorporating insitu synthesis of DNA probes, as compared to the conventional functionalization method employing pre-synthesized DNA probe immobilization.
Keywords :
DNA; biochemistry; biosensors; chemical sensors; photonic crystals; functionalization method; in-situ synthesized DNA probe immobilization; multihole defect photonic crystal biosensor; sensitivity enhancement; Biosensors; DNA; Magnetohydrodynamics; Optical surface waves; Photonic crystals; Probes; Silicon; Biosensor; DNA detection; In-situ DNA synthesis; Label-free; Photonic crystal;
Conference_Titel :
Photonics Conference (IPC), 2013 IEEE
Conference_Location :
Bellevue, WA
Print_ISBN :
978-1-4577-1506-8
DOI :
10.1109/IPCon.2013.6656486
