Steady-state optimal insulin infusion for hyperglycemic ICU patients

Close control of blood glucose levels significantly reduces vascular complications in diabetes, as well as having beneficial effect for cardiac and other critical care patients. Recent studies have shown that tight regulation of blood glucose level in intensive care unit patients can reduce mortality by as much as 45%. This paper presents an optimal insulin infusion algorithm to tightly regulate blood glucose for ICU and other critical care patients when the glucose input is known. Results show an ideal, flat blood glucose response when subjected to a typical ICU glucose input as well as for a far more extreme case.