Simulations and visualizations for interpretation of brain microdialysis data during deep brain stimulation

Author

Diczfalusy, Elin ; Dizdar, N. ; Zsigmond, P. ; Kullman, A. ; Loyd, D. ; Wardell, Karin

Author_Institution

Dept. of Biomed. Eng., Linkoping Univ., Linkoping, Sweden

fYear

2012

fDate

Aug. 28 2012-Sept. 1 2012

Firstpage

6438

Lastpage

6441

Abstract

Microdialysis of the basal ganglia was used in parallel to deep brain stimulation (DBS) for patients with Parkinson´s disease. The aim of this study was to patient-specifically simulate and visualize the maximum tissue volume of influence (TVI_max) for each microdialysis catheter and the electric field generated around each DBS electrode. The finite element method (FEM) was used for the simulations. The method allowed mapping of the anatomical origin of the microdialysis data and the electric stimulation for each patient. It was seen that the sampling and stimulation targets differed among the patients, and the results will therefore be used in the future interpretation of the biochemical data.

Keywords

bioelectric phenomena; biological tissues; biomedical electrodes; brain; catheters; finite element analysis; patient treatment; DBS; FEM; Parkinson disease; basal ganglia; biochemical data; catheter; deep brain stimulation; finite element method; maximum tissue influence volume; microdialysis; Biological system modeling; Brain modeling; Brain stimulation; Catheters; Electric fields; Mathematical model; Satellite broadcasting; Brain; Deep Brain Stimulation; Electrodes; Finite Element Analysis; Humans; Microdialysis; Middle Aged;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE

Conference_Location

San Diego, CA

ISSN

1557-170X

Print_ISBN

978-1-4244-4119-8

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/EMBC.2012.6347468

Filename

6347468