DocumentCode :
2121720
Title :
Sensitivity analysis of Wnt Signaling Pathway
Author :
Azam, M.R. ; Bhatti, Aamer Iqbal ; Arshad, Abida ; Babar, M.Z.
Author_Institution :
Muhammad Ali Jinnah Univ. Islamabad, Islamabad, Pakistan
fYear :
2013
fDate :
15-19 Jan. 2013
Firstpage :
122
Lastpage :
127
Abstract :
Wnt pathway plays a vital role in embryonic and early development, cell differentiation, cell polarity generation, stem cell maintenance, tissue repair, tissue development, and in cancer initiation. A group of proteins regulate the level of β-catenin inside the cell. Disregulation of this pathway becomes a cause of many human diseases like bone diseases and colorectal cancer. In this paper modal analysis is carried out for an existing mathematical model of Wnt Pathway. By modal analysis, time constants of proteins or protein complexes are calculated, states which do not satisfy the required criteria, have been proposed to be ignored for further analysis. Sensitivity analysis for this Pathway is conducted to identify most effective (hence important) parameters, for which the system´s response is most sensitive. We have carried out different variations in parameters and studied change in the course of concentrations. The sensitivity analysis and simulation studies guide us towards the fact that system output is more sensitive to axin dependent destruction complex rate constant.
Keywords :
biology; bone; cancer; cellular biophysics; modal analysis; proteins; sensitivity analysis; β-catenin; Wnt signaling pathway; bone disease; cancer initiation; cell differentiation; cell polarity generation; colorectal cancer; complex rate constant; embryonic development; human disease; mathematical model; modal analysis; pathway disregulation; protein complex; sensitivity analysis; stem cell maintenance; system output; system response; time constant; tissue development; tissue repair; Analytical models; Barium; Equations; Modal analysis; Proteins; Sensitivity analysis;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Applied Sciences and Technology (IBCAST), 2013 10th International Bhurban Conference on
Conference_Location :
Islamabad
Print_ISBN :
978-1-4673-4425-8
Type :
conf
DOI :
10.1109/IBCAST.2013.6512143
Filename :
6512143
Link To Document :
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