Physiome of coronary circulation: simulation of autoregulated coronary flow

Author

Kagiyama, M. ; Ogasawara, Y. ; Hiramatsu, O. ; Tachibana, H. ; Kajiya, F. ; Kagotani, H. ; Okamoto, T.

Author_Institution

Dept. of Clinical Eng., Hiroshima Int. Univ., Kurose, Japan

fYear

2001

fDate

2001

Firstpage

353

Lastpage

356

Abstract

The purpose of this study was to explain intramyocardial coronary microvascular diameter changes during a cardiac cycle observed with our needle-probe CCD videomicroscope by a model simulation. An autoregulated coronary flow model was constructed by including a control element that regulates bloodflow by tuning myocardial elastance to our previous model. The relationship between mean flow and perfusion pressure, determined by model experiments, coincided well with the published data. The relative maximal arteriolar diameters in a cardiac cycle were calculated based on simulation. The changes in the diameters were small, coinciding with the experimental observation

Keywords

CCD image sensors; biocontrol; blood vessels; cardiovascular system; haemodynamics; haemorheology; optical microscopy; physiological models; simulation; autoregulated coronary flow simulation; blood flow regulation; cardiac cycle; coronary circulation; intramyocardial coronary microvascular diameter changes; mean flow; myocardial elastance tuning; needle-probe CCD videomicroscope; perfusion pressure; physiome; relative maximal arteriolar diameters; Blood flow; Blood pressure; Blood vessels; Cardiology; Charge coupled devices; Equations; Medical simulation; Myocardium; Pressure control; Veins;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology 2001

Conference_Location

Rotterdam

ISSN

0276-6547

Print_ISBN

0-7803-7266-2

Type

conf

DOI

10.1109/CIC.2001.977665

Filename

977665