Title :
Physiome of coronary circulation: simulation of autoregulated coronary flow
Author :
Kagiyama, M. ; Ogasawara, Y. ; Hiramatsu, O. ; Tachibana, H. ; Kajiya, F. ; Kagotani, H. ; Okamoto, T.
Author_Institution :
Dept. of Clinical Eng., Hiroshima Int. Univ., Kurose, Japan
Abstract :
The purpose of this study was to explain intramyocardial coronary microvascular diameter changes during a cardiac cycle observed with our needle-probe CCD videomicroscope by a model simulation. An autoregulated coronary flow model was constructed by including a control element that regulates bloodflow by tuning myocardial elastance to our previous model. The relationship between mean flow and perfusion pressure, determined by model experiments, coincided well with the published data. The relative maximal arteriolar diameters in a cardiac cycle were calculated based on simulation. The changes in the diameters were small, coinciding with the experimental observation
Keywords :
CCD image sensors; biocontrol; blood vessels; cardiovascular system; haemodynamics; haemorheology; optical microscopy; physiological models; simulation; autoregulated coronary flow simulation; blood flow regulation; cardiac cycle; coronary circulation; intramyocardial coronary microvascular diameter changes; mean flow; myocardial elastance tuning; needle-probe CCD videomicroscope; perfusion pressure; physiome; relative maximal arteriolar diameters; Blood flow; Blood pressure; Blood vessels; Cardiology; Charge coupled devices; Equations; Medical simulation; Myocardium; Pressure control; Veins;
Conference_Titel :
Computers in Cardiology 2001
Conference_Location :
Rotterdam
Print_ISBN :
0-7803-7266-2
DOI :
10.1109/CIC.2001.977665
