Title :
Phase-sentitive bloch surface wave biosensors
Author :
Sinibaldi, A. ; Anopchenko, A. ; Rizzo, R. ; Michelotti, F. ; Danz, N. ; Munzert, P. ; Rivolo, P. ; Ricciardi, S. ; Frascella, F.
Author_Institution :
Dept. of Basic & Appl. Sci. for Eng., SAPIENZA Univ. of Rome, Rome, Italy
Abstract :
We report on the practical implementation of an angularly resolved ellipsometric optical sensing scheme based on Bloch surface waves sustained by tantala/titania/silica multilayers. The angular resolution is obtained by a focused illumination at fixed wavelength and detecting the angular reflectance spectrum by means of a CMOS array detector. The experimental results, obtained by using one tantala/titania/silica/multilayer defined structure, show the limit of detection below 6.5*10-7 RIU/Hz1/2. The physical characterization of the biosensors and their practical use with biological protocols is reported.
Keywords :
CMOS integrated circuits; biochemistry; biosensors; chemical sensors; multilayers; optical sensors; silicon compounds; surface plasmon resonance; tantalum compounds; titanium compounds; CMOS array detector; Ta2O5-TiO2-SiO2; angular reflectance spectrum; angular resolution; angular resolved ellipsometric optical sensor; biological protocols; detection limit; phase-sentitive bloch surface wave biosensors; physical characterization; tantala-titania-silica multilayers; Biomedical optical imaging; Biosensors; Optical sensors; Optical surface waves; Proteins; Refractive index; Surface waves; Bloch surface waves; biophotonics; ellipsometry; label-free biosensors; optical biosensing; photonic crystals;
Conference_Titel :
AISEM Annual Conference, 2015 XVIII
Conference_Location :
Trento
DOI :
10.1109/AISEM.2015.7066790
