Phase-sentitive bloch surface wave biosensors

Author

Sinibaldi, A. ; Anopchenko, A. ; Rizzo, R. ; Michelotti, F. ; Danz, N. ; Munzert, P. ; Rivolo, P. ; Ricciardi, S. ; Frascella, F.

Author_Institution

Dept. of Basic & Appl. Sci. for Eng., SAPIENZA Univ. of Rome, Rome, Italy

fYear

2015

fDate

3-5 Feb. 2015

Firstpage

1

Lastpage

4

Abstract

We report on the practical implementation of an angularly resolved ellipsometric optical sensing scheme based on Bloch surface waves sustained by tantala/titania/silica multilayers. The angular resolution is obtained by a focused illumination at fixed wavelength and detecting the angular reflectance spectrum by means of a CMOS array detector. The experimental results, obtained by using one tantala/titania/silica/multilayer defined structure, show the limit of detection below 6.5*10^-7 RIU/Hz^1/2. The physical characterization of the biosensors and their practical use with biological protocols is reported.

Keywords

CMOS integrated circuits; biochemistry; biosensors; chemical sensors; multilayers; optical sensors; silicon compounds; surface plasmon resonance; tantalum compounds; titanium compounds; CMOS array detector; Ta₂O₅-TiO₂-SiO₂; angular reflectance spectrum; angular resolution; angular resolved ellipsometric optical sensor; biological protocols; detection limit; phase-sentitive bloch surface wave biosensors; physical characterization; tantala-titania-silica multilayers; Biomedical optical imaging; Biosensors; Optical sensors; Optical surface waves; Proteins; Refractive index; Surface waves; Bloch surface waves; biophotonics; ellipsometry; label-free biosensors; optical biosensing; photonic crystals;

fLanguage

English

Publisher

ieee

Conference_Titel

AISEM Annual Conference, 2015 XVIII

Conference_Location

Trento

Type

conf

DOI

10.1109/AISEM.2015.7066790

Filename

7066790