Title :
Sensitivity and Limit of detection of biosensors based on ring resonators
Author :
Gandolfi, D. ; Guider, R. ; Chalyan, T. ; Pavesi, L. ; Pasquardini, L. ; Pederzolli, C. ; Samusenko, A. ; Pucker, G.
Author_Institution :
Dept. of Phys., Univ. of Trento, Povo, Italy
Abstract :
In this article, we compared different silicon oxynitride (SiON) microring-based photonic structures for biosensing applications. We varied the refractive index of SiON as well as the dimensions of the resonators, and analyzed their volumetric sensitivity and limit of detection by using glucose-water solutions. By functionalizing the surface of these sensors, we also investigated the specific detection of Aflatoxin M1. We observed binding of aflatoxin at concentrations as low as 12.5nM, and regeneration of a single functionalized sample up to 17 times by using glycine solution. The results open up the path for designing cost effective biosensors for a fast and reliable sensitive analysis of AFM1 in milk.
Keywords :
CMOS integrated circuits; biosensors; cellular biophysics; microcavities; micromechanical resonators; microorganisms; optical resonators; optical waveguides; refractive index; silicon compounds; toxicology; vapour deposited coatings; SiON detection limit; SiON microring-based photonic structures; SiON refractive index; SiON volumetric sensitivity; aflatoxin binding concentrations; biosensor detection limit; biosensor sensitivity; biosensor-based aflatoxin M1 detection; cost effective biosensor design; fast milk AFM1 analysis; fast milk aflatoxin M1 analysis; glucose-water solutions; glycine solution; reliable milk AFM1 analysis; reliable milk aflatoxin M1 analysis; ring resonator dimensions; ring resonator-based biosensor; sensitive milk AFM1 analysis; sensitive milk aflatoxin M1 analysis; sensor surface functionalization; silicon oxynitride detection limit; silicon oxynitride microring-based photonic structures; silicon oxynitride refractive index; silicon oxynitride volumetric sensitivity; single functionalized sample regeneration; specific aflatoxin M1 detection; Biosensors; Optical resonators; Optical waveguides; Photonics; Refractive index; Sensitivity; Aflatoxin; Limit of Detection; biosensor; ring resonator; sensitivity; waveguide;
Conference_Titel :
AISEM Annual Conference, 2015 XVIII
Conference_Location :
Trento
DOI :
10.1109/AISEM.2015.7066797
