Title :
Electrochemical sensor for Serotonin based on a composite made of core-shell molecularly imprinted polymer nanoparticles and polyethilenedioxythiophene
Author :
Introna, Barbara ; Malitesta, Cosimino ; Mazzotta, Elisabetta ; Rella, Simona ; Mohammadi, Reza ; Ramezany, Farid ; Sellergren, Borje
Author_Institution :
Dipt. di Sci. e Tecnol. Biologiche ed Ambientali, Univ. del Salento, Lecce, Italy
Abstract :
The “grafting from” synthesis of core-shell molecularly imprinted polymer nanoparticles (Ser-MIP@SiO2 NPs) has been applied to the development of an electrochemical sensor for Serotonin. Ser-MIP@SiO2 NPs have been synthesized on preformed SiO2 nanobeads by surface imprinting via reversible additionfragmentation chaintransfer (RAFT) polymerization. After polymerization, the reductive aminolysis of dithioesther end group has been carried out. Then MIP-nanoparticles were subsequently characterized by ATR-FTIR, TGA, TEM and XPS. The entrapment of core-shell Ser-MIP@SiO2 NPs by the electropolymerization of PEDOT in an upside-down electrochemical cell has been investigated. Under selected conditions, results in sensing application for Serotonin are presented.
Keywords :
Fourier transform infrared spectra; X-ray photoelectron spectra; attenuated total reflection; biochemistry; biosensors; core levels; core-shell nanostructures; electrochemical sensors; nanocomposites; nanofabrication; nanomedicine; nanoparticles; polymerisation; polymers; silicon compounds; transmission electron microscopy; ATR-FTIR; Fourier transform infrared spectra; MIP-nanoparticle; PEDOT electropolymerization; RAFT polymerization; Ser-MIP-SiO2 nanoparticle synthesis; SiO2; X-ray photoelectron spectra; attenuated total reflectance; core-shell Ser-MIP-SiO2 nanoparticle entrapment; core-shell molecularly imprinted polymer nanoparticle; dithioesther end group reductive aminolysis; electrochemical sensor development; polyethilenedioxythiophene; reversible addition fragmentation chaintransfer; serotonin; silicon dioxide nanobeads; surface imprinting; thermal gravimetric analysis; transmission electron microscopy; Chemicals; Electrodes; Films; Nanoparticles; Polymers; Silicon compounds; core-shell nanoparticles; electrochemical sensors; molecularly imprinted polymers; polyethylenedioxythiophene (PEDOT); serotonin;
Conference_Titel :
AISEM Annual Conference, 2015 XVIII
Conference_Location :
Trento
DOI :
10.1109/AISEM.2015.7066843
