Lab-on-a-chip sensor for measuring zinc in blood serum

Author

Jothimuthu, P. ; Wilson, R.A. ; Sukavasi, S. ; Herren, J. ; Wong, H. ; Beyette, F.R. ; Heineman, W.R. ; Papautsky, I.

Author_Institution

Sch. of Electron. & Comput. Syst., Univ. of Cincinnati, Cincinnati, OH, USA

fYear

2010

fDate

1-4 Nov. 2010

Firstpage

1222

Lastpage

1225

Abstract

This work describes the development of an electrochemical sensor for point-of-care measurement of zinc in blood serum. The sensor is based on the anodic stripping voltammetry (ASV) and consists of a three-electrode system including bismuth working electrode, an on-chip Ag/AgCl reference electrode, and a Au auxiliary electrode. The demonstrated sensor allowed rapid and accurate measurement of zinc in the physiological range (65~95 μg/dL). Thus, the developed lab-on-a-chip sensor permits measurement of Zn in blood serum with reduced sample volumes (200 μL from a drop of blood from a finger prick) and reduced turnaround time (10~20 min). Ultimately, this system will permit the quantification of Zn at the bedside of critically ill patients.

Keywords

biochemistry; biomedical materials; biomedical measurement; biosensors; electrochemical electrodes; electrochemical sensors; lab-on-a-chip; molecular biophysics; proteins; voltammetry (chemical analysis); zinc; Zn; anodic stripping voltammetry; auxiliary electrode; bismuth working electrode; blood serum; electrochemical sensor; lab-on-a-chip sensor; point-of-care measurement; three-electrode system; zinc;

fLanguage

English

Publisher

ieee

Conference_Titel

Sensors, 2010 IEEE

Conference_Location

Kona, HI

ISSN

1930-0395

Print_ISBN

978-1-4244-8170-5

Electronic_ISBN

1930-0395

Type

conf

DOI

10.1109/ICSENS.2010.5690623

Filename

5690623