Title :
A biophysical model of the synergistic interaction of environmental agents
Author :
Komarov, V.P. ; Petin, V.G.
Author_Institution :
Biophys. Lab., Acad. of Med. Sci., Obninsk, Russia
Abstract :
The authors have proposed a simple mathematical model of synergistic interaction of various environmental physical and chemical agents. The model suggests that synergism is expected to result from an additional lethal damage arising from the interaction of sub-lesions induced by both agents. The model allows quantitatine optimisation of the combined action of two harmful agents and predicts the maximum value of the synergistic effect and conditions under which it can be achieved. The prediction of the model have bees tested using published experimental data. It is concluded that synergistic interaction can take place between an existing background of ionizing radiation, natural UV-radiation, hyperthermia and chemical pollution and thereby strengthen their harmful influence on health quality
Keywords :
biological effects of ionising radiation; biological effects of ultraviolet radiation; health hazards; hyperthermia; physiological models; pollution; additional lethal damage; biophysical model; chemical agents; chemical pollution; environmental agents; harmful agents; harmful influence; health quality; hyperthermia; ionizing radiation; natural UV-radiation; physical agents; simple mathematical model; sub-lesion interaction; synergistic interaction; Biological system modeling; Chemicals; Ionizing radiation; Lesions; Mathematical model; Medical services; Pollution; Predictive models; Radiology; Testing;
Conference_Titel :
Engineering in Medicine and Biology Society, 1995 and 14th Conference of the Biomedical Engineering Society of India. An International Meeting, Proceedings of the First Regional Conference., IEEE
Conference_Location :
New Delhi
Print_ISBN :
0-7803-2711-X
DOI :
10.1109/RCEMBS.1995.508693
