Study on the Specific ncRNAs Based on Z-curve Method

Because of non-coding sequences playing more and more important roles in the process of translation, it has very important significance to research non-coding region and its function. In the recent years, the researches have been made great progress on the non-coding regions, especially about non-protein-coding RNA (ncRNAs). The Z curve is a very useful method for visualizing and analyzing DNA sequences. It is a three-dimensional space curve constituting the unique representation of a given DNA sequence in the sense that each can be uniquely reconstructed from the other. Based on the Z curve, this paper picks up 20 Specific ncRNAs (BC200 RNA and BC1 RNA) sequences from the NONCODE database, which relate with disease-cancer and come from different organisms. The corresponding Z curves of the ncRNAs sequences have been mapped and compared. The geometrical features of the studied ncRNA sequences are obtained. These features indicate the ncRNA sequences having same functions have almost same Z-curve shapes or tendency and base content in spite of difference of organisms.