Multidrug infusion control using an indirect adaptive pole placement algorithm

This paper presents the application of a multivariable, indirect-adaptive pole placement controller to a physiological system. Although highly nonlinear, the system will be modelled by a difference equation, which is initially identified off-line. As the system evolves the model is updated via online recursive identification and the controller is correspondingly updated. An example is given, which illustrates the ability of the controller to adapt in response to changing system dynamics