• DocumentCode
    2156248
  • Title

    Parameter estimation of pharmacokinetics models in the presence of timing noise

  • Author

    Bastogne, Thierry ; Mezieres-Wantz, Sophie ; Ramdani, Nacim ; Vallois, Pierre ; Barberi-Heyob, Muriel

  • Author_Institution
    Centre de Rech. en Autom. de Nancy, Nancy-Univ., Vandoeuvre-lès-Nancy, France
  • fYear
    2007
  • fDate
    2-5 July 2007
  • Firstpage
    2450
  • Lastpage
    2455
  • Abstract
    The problem addressed in this paper deals with the parameter estimation of in vitro uptake kinetics of drugs into living cells in presence of timing noise. Effects of the timing noise on the bias and variance of the output error are explicitly determined. A bounded-error parameter estimation approach is proposed as a suited solution to handle this problem. Application results are presented and emphasize its effectiveness in such an experimental framework.
  • Keywords
    cellular biophysics; drugs; parameter estimation; bounded error parameter estimation approach; drugs; living cells; pharmacokinetics models; timing noise; Drugs; In vitro; Kinetic theory; Noise; Parameter estimation; Timing; biological systems; bounded errors; parameter estimation; pharmacokinetics models; timing errors;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Control Conference (ECC), 2007 European
  • Conference_Location
    Kos
  • Print_ISBN
    978-3-9524173-8-6
  • Type

    conf

  • Filename
    7068380
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=2156248