Modeling capacitance relaxation phenomena of malignant membrane in tumor angiogenesis due to Vascular Endothelial Growth Factor

Electrical impedance scanning (EIS) is a new technique in which moderate variations in capacitance values are reflected by the cells of various type of normal membrane. The malignant membrane of vascular endothelial cell in association with VEGF (vascular endothelial growth factor), in contrast, EIS demonstrates significant capacitance relaxation phenomena concomitant with alpha-dispersion in the low audio frequency range. The author has endeavoured to establish the above stated phenomena. In this experimental setup, the lipo-protein constituent of the membrane was dissolved in acetone solvent and the interaction of the dissolved lipoprotein in the presence of electrical stimuli in the lower audio frequency range at room temp about 25degC was studied. The capacitance relaxation phenomena concomitant with dispersion in malignant membrane for subjects below and above 50 years has been simulated in MATLAB 6.5. The model incorporates a modified homeostat comprising of homeostat and transduction phase in the feedback path and it represents the interaction of the lipoprotein in malignant membrane associated with alpha-dispersion mediated through capacitance relaxation phenomena. Results from the output of the model are in close conformity with the capacitance relaxation phenomena which suggest an adjunctive detection modality in the differentiation of membrane malignancy in respect of co- relation of VEGF and alpha-dispersion established by authors.