Deep Capture of Paramagnetic Particle for Targeting Therapeutics

Author

Gong, Yongyong ; Pei, Ning ; Huang, Zheyong ; Ge, Junbo ; Ma, Wenli ; Zheng, Wenling

Author_Institution

Coll. of Sci., Shanghai Univ., Shanghai, China

fYear

2009

fDate

17-19 Oct. 2009

Firstpage

1

Lastpage

4

Abstract

Magnetic targeting, a promising therapeutic strategy for localizing systemically-delivered drug to target tissue, is limited by magnetic attenuation. A special apparatus was developed to fulfill deep magnetic targeting. Due to special shape of poles and magnetic shields, the magnetic field produced by this apparatus was stronger at the center of the air gap than any other place along two directions. The magnetic field could make deep capturing along these directions. To test the aggregation property of this apparatus, the accumulation of 500-nm paramagnetic particles was observed as flowing through a tube served as a model of blood vessels. The relationship of the accumulation of the paramagnetic particles and effectiveness of the magnetic shielding was studied.

Keywords

biomagnetism; blood vessels; drugs; magnetic shielding; nanobiotechnology; nanoparticles; paramagnetic materials; physiological models; aggregation property; blood vessel model; magnetic shielding; magnetic targeting; paramagnetic particle; size 500 nm; therapeutic targeting; tube model; Blood vessels; Drugs; Magnetic fields; Magnetic flux; Magnetic flux density; Magnetic levitation; Magnetic shielding; Neoplasms; Paramagnetic materials; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering and Informatics, 2009. BMEI '09. 2nd International Conference on

Conference_Location

Tianjin

Print_ISBN

978-1-4244-4132-7

Electronic_ISBN

978-1-4244-4134-1

Type

conf

DOI

10.1109/BMEI.2009.5304841

Filename

5304841