Could Traditional Chinese Medicine Used for Curing Erectile Dysfunction?

Author

Chen, Chien-Yu ; Bau, Da-Tian ; Tsai, Ming-Hsui ; Hsu, Yuan-Man ; Ho, Tin-Yun ; Huang, Hung-Jin ; Chang, Yea-Huey ; Tsai, Fuu-Jen ; Tsai, Chang-Hai ; Chen, Calvin Yu-Chian

Author_Institution

Dept. of Biol. Sci. & Technol., China Med. Univ., Taichung, Taiwan

fYear

2009

fDate

17-19 Oct. 2009

Firstpage

1

Lastpage

5

Abstract

This study could show that the potent inhibitor of PDE5 from Epimedium sagittatum components. The PDE 5 inhibitors of data set from Xia´s study were calculated their properties. Multiple linear regression analysis was used to build the QSAR model. Those properties were associated to drug activities by the QSAR model. This result showed high correlation (R2 = 0.848) with drug activities in this QSAR model. The weights of those properties were -5.359, 6.434, -3.959, 5.149, and 8.689. In the result of prediction, the correlation was employed to predict pIC50 of the ES series (Cialis = 7.988, ES02 = 6.31, ES03a = 9.78, ES03b = 10.03). The docking protocol was used to prove the trend of prediction. This result showed the same trend in docking scores (Cialis = 53.271, ES02 = 57.864, ES03a = 64.260, ES03b = 76.915). According to those results, ES03b was elevated to be a potent inhibitor of PDE5.

Keywords

biochemistry; medicine; patient treatment; regression analysis; Epimedium sagittatum; PDE5 inhibitor; QSAR model; drug activities; erectile dysfunction; linear regression analysis; traditional chinese medicine; Asia; Biochemistry; Construction; Curing; Degradation; Drugs; Hospitals; Inhibitors; Medical treatment; Muscles;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering and Informatics, 2009. BMEI '09. 2nd International Conference on

Conference_Location

Tianjin

Print_ISBN

978-1-4244-4132-7

Electronic_ISBN

978-1-4244-4134-1

Type

conf

DOI

10.1109/BMEI.2009.5304967

Filename

5304967